The Irish twosome – who found fame on the 2009 series of The X Factor – will perform their current single, a cover of Blink 182’s All The Small Things, live on Friday evening’s eviction show.
“We’re extremely honoured to be the first people in the show’s history to go into the Big Brother house to do a performance,” the pair said.
“We’re so excited to get in there and see the housemates face to face.”
An show insider told music channel MTV: “Love them or hate them, Jedward are hilarious to watch and they’re bound to boost the ratings.
“As it’s the last series, producers are doing everything they can to make the Friday night shows unmissable – and with the twins performing, this week’s eviction will be just that.”
John and Edward sprang to stardom after they reached the finals of The X Factor in 2009.
The pair gained a huge following despite constant criticism from the judges, and eventually finished in sixth place. They reached number two in the charts earlier this year with debut single Under Pressure.