In Huntington, West Virginia, one in four adults is addicted to heroin or other opiates.

The rate of fatal overdoses is 13 times higher than the US national average and one in 10 babies is born dependent on opiates.

As he begins a new series, Louis Theroux visits the Appalachian city to find out the reason for these horrifying statistics, meeting addicts, their families and the emergency services struggling to keep up with the fallout.

It’s pretty bleak, but even so there are glimmers of hope in this moving film, such as former user Mickey, one year sober and passionately trying to pull others out of terrible situations, and pregnant Alisha, who is determined to put her past behind her.