A cracking qualifier, this match sees top of the qualifying table Wales host second-placed England (k-o 7.45pm) at Rodney Parade, Newport.
But England are just a single point behind, and have another game after this against minnows Kazakhstan, while this is the final game Wales will play in the qualifiers.
Wales need to win this, but their best result against England was the 0-0 draw that played out back in April.
England, meanwhile, are likely to end up topping the table and make it to the World Cup in France next year.
Can Wales pull off an upset here?