Kutcher – who is married to actress Demi Moore – is no stranger to the small screen, having starred in the sitcom That 70s Show as well as having hosted the prank show Punk’d.
He is taking over after Sheen was dismissed from the show following a tirade against the producers, as well as his highly-publicised problems with drugs and alcohol.
“I can’t replace Sheen but I’m going to work my ass off to entertain people,” Kutcher said after the news was announced.
Earlier he had hinted on his Twitter page that the role was his, with the cryptic comment “What’s the square root of 6.25?”
Chuck Lorre, the show’s creator and executive producer, added, “We are so lucky to have someone as talented, joyful and just plain remarkable as Ashton joining our family,”
“Added to that is the deep sigh of relief knowing that our family stays together. If I was any happier, it’d be illegal.”
Sheen starred as jingle writer Charlie Harper on the show, which is one of the most popular programmes on US TV.
He was in the middle of appearing on the eighth series when he was sacked, leading to the season being cut short.