The award-winning comedy has welcomed stars from the science, sci-fi and comic-book worlds such as Professor Stephen Hawking, James Earl Jones, George Takei, Carrie Fisher and Stan Lee.
The cast of The Big Bang Theory (Channel 4/CBS)
But there’s a certain Friend that remains on the actor’s wishlist.
“I still want to work with Lisa Kudrow. I’ve always thought about her for the show,” he said.
Lisa Kudrow (Jordan Strauss/Invision)
“I don’t know what part – I guess I’d leave that for the writers – but I’m a big fan of hers and I would love to have her on.”
The 41-year-old star, who has won four Emmy awards for his portrayal of socially awkward theoretical physicist Sheldon Cooper on the US show, admitted he is baffled by the show’s scientific references and often doesn’t understand a lot of the complicated lingo.
“I understand enough to look like I understand what I’m talking about is how I would put it,” he said.
“The science stuff I rarely understand more than how to pronounce the words and what order they go in, and I’m dead serious about that.”
Jim Parsons with his Big Bang Theory co-stars (Chris Pizzello/Invision)
The actor added: “The conversational stuff, I understand all of that. He still has a weird way of putting words together even when it’s normal talk.”
Jim – who voices an alien in DreamWorks’ new animated movie Home – also revealed he always gets a “warm” response from the public.
“It’s a very warm reaction always, and the only thing I find funny about that is I would think people might think Sheldon might be a little off-putting,” he said. “But people don’t approach me that way at all. People are eager and warm.”
Home is in cinemas now, while The Big Bang Theory continues on E4 on Thursdays.